Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
about
Customizing the genome as therapy for the β-hemoglobinopathiesHMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts.Recent advances in globin research using genome-wide association studies and gene editing.SIRT1 activates the expression of fetal hemoglobin genesTough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells.Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the beta-like globin locus in juvenile myelomonocytic leukemia.The future of academic haematology.Protein-based therapeutic for anemia caused by dyserythropoiesis.Regulation of hematopoietic development by ZBTB transcription factors.Treating hemoglobinopathies using gene-correction approaches: promises and challenges.Hemoglobin genetics: recent contributions of GWAS and gene editing.Emerging cellular and gene therapies for congenital anemias.Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches.Gene Therapy for β-Hemoglobinopathies.Molecular basis of β thalassemia and potential therapeutic targets.Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents.An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination.Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemiaTherapeutic advances in sickle cell disease in the last decade.Fetal haemoglobin induction in sickle cell disease.Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders.Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.Evolution of hemoglobin loci and their regulatory elements.A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression.Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights and Therapeutic Applications.A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.Genome Editing of Erythroid Cell Culture Model Systems.Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.Growing and Genetically Manipulating Human Umbilical Cord Blood-Derived Erythroid Progenitor (HUDEP) Cell Lines.Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing.Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered ErythropoiesisDisruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major
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P2860
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
description
2016 nî lūn-bûn
@nan
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
name
Transcription factors LRF and ...... xpression of fetal hemoglobin.
@ast
Transcription factors LRF and ...... xpression of fetal hemoglobin.
@en
type
label
Transcription factors LRF and ...... xpression of fetal hemoglobin.
@ast
Transcription factors LRF and ...... xpression of fetal hemoglobin.
@en
prefLabel
Transcription factors LRF and ...... xpression of fetal hemoglobin.
@ast
Transcription factors LRF and ...... xpression of fetal hemoglobin.
@en
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P2860
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Transcription factors LRF and ...... xpression of fetal hemoglobin.
@en
P2093
Alister P W Funnell
Catherine Zhu
Chris Fisher
Daniel E Bauer
Falak Sher
Gabriella E Martyn
Manami Maeda
Peter V Kharchenko
Ryo Kurita
P2860
P304
P356
10.1126/SCIENCE.AAD3312
P407
P577
2016-01-01T00:00:00Z