Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.
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Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vectorThe variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunitsProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingHuman immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2Ap53-dependent association between cyclin G and the B' subunit of protein phosphatase 2ARegulation of human adenovirus alternative RNA splicing by the adenoviral L4-33K and L4-22K proteinsMechanisms of cancer cell killing by the adenovirus E4orf4 proteinThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseStructure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunitAdenovirus E4orf4 protein induces PP2A-dependent growth arrest in Saccharomyces cerevisiae and interacts with the anaphase-promoting complex/cyclosome.Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases.Cytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Localization and importance of the adenovirus E4orf4 protein during lytic infectionAnalysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGFDirected evolution generates a novel oncolytic virus for the treatment of colon cancerNovel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytesThe cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.Regulation of adenovirus-mediated transgene expression by the viral E4 gene products: requirement for E4 ORF3.Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Complex energy landscape of a giant repeat protein.Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cellsAdenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisBiology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmkDistinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein.Cdc55p-mediated E4orf4 growth inhibition in Saccharomyces cerevisiae is mediated only in part via the catalytic subunit of protein phosphatase 2A.Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsPP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in CancerA gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4.
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P2860
Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Adenovirus E4orf4 protein bind ...... A-enhanced junB transcription.
@ast
Adenovirus E4orf4 protein bind ...... A-enhanced junB transcription.
@en
type
label
Adenovirus E4orf4 protein bind ...... A-enhanced junB transcription.
@ast
Adenovirus E4orf4 protein bind ...... A-enhanced junB transcription.
@en
prefLabel
Adenovirus E4orf4 protein bind ...... A-enhanced junB transcription.
@ast
Adenovirus E4orf4 protein bind ...... A-enhanced junB transcription.
@en
P2860
P1433
P1476
Adenovirus E4orf4 protein bind ...... 1A-enhanced junB transcription
@en
P2093
T Kleinberger
P2860
P304
P407
P577
1993-12-01T00:00:00Z