Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends - sprookjes - yvandenbroek - TriplyDB

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

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DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens Telomere dysfunction and chromosome instability The convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancer Processing of damaged DNA ends for double-strand break repair in mammalian cells Homology and enzymatic requirements of microhomology-dependent alternative end joining ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks Double strand break repair functions of histone H2AX Role of mammalian Mre11 in classical and alternative nonhomologous end joining MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings A noncatalytic function of the ligation complex during nonhomologous end joining.Limiting the persistence of a chromosome break diminishes its mutagenic potential.The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line.PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.An end-joining repair mechanism in Escherichia coli.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination.Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line Sequence conversion by single strand oligonucleotide donors via non-homologous end joining in mammalian cells TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions.The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.Mechanisms of double-strand break repair in somatic mammalian cells.HTLV-I tax increases genetic instability by inducing DNA double strand breaks during DNA replication and switching repair to NHEJ.Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.Damaging the Integrated HIV Proviral DNA with TALENs.ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line.

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Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

http://www.wikidata.org/entity/Q36693356

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2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

@ast

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

@en

type

label

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

@ast

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

@en

prefLabel

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

@ast

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

@en

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Proceedings of the National Academy of Sciences of the United States of America

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Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

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Bernard S Lopez

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Emilie Rass

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Isabelle Plo

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Josée Guirouilh-Barbat

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Pascale Bertrand

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P2860

Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

Chromosome translocation based on illegitimate recombination in human tumors

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

IgH class switching and translocations use a robust non-classical end-joining pathway

Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

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20902-20907

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104

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5755006

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18093953

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2409239

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