Structure-function-rescue: the diverse nature of common p53 cancer mutants.
about
Transcriptional regulation of the tumor suppressor FHL2 by p53 in human kidney and liver cellsIntrinsically disordered proteins in a physics-based worldQuaternary structures of tumor suppressor p53 and a specific p53 DNA complexReactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancerElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsProtein-protein interaction networks: probing disease mechanisms using model systemsAcetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitroG-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.Targeted rescue of a destabilized mutant of p53 by an in silico screened drugStabilising the DNA-binding domain of p53 by rational design of its hydrophobic coreStructural evolution of p53, p63, and p73: Implication for heterotetramer formationInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerSolution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequenceSmall molecule induced reactivation of mutant p53 in cancer cellsHalogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsAn integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencingTargeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alphaModulation of the disordered conformational ensembles of the p53 transactivation domain by cancer-associated mutationsPhosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3Functional interplay between MDM2, p63/p73 and mutant p53Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism.Early onset sebaceous carcinoma.Fusaric Acid Induces DNA Damage and Post-Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2 ) Cells.Stability of the core domain of p53: insights from computer simulations.Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survivalp53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.Characterization of a new mouse p53 variant: loss-of-function and gain-of-function.TP53 mutations in human cancers: origins, consequences, and clinical useA novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function.Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain.Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesThe protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation.Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomasE2F1 mediated apoptosis induced by the DNA damage response is blocked by EBV nuclear antigen 3C in lymphoblastoid cells.Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism
P2860
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P2860
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@ast
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@en
type
label
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@ast
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@en
prefLabel
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@ast
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@en
P356
P1433
P1476
Structure-function-rescue: the diverse nature of common p53 cancer mutants.
@en
P2093
A C Joerger
A R Fersht
P2888
P304
P356
10.1038/SJ.ONC.1210291
P407
P577
2007-04-01T00:00:00Z