Identification of the lytic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination.
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Human cytomegalovirus plasmid-based amplicon vector system for gene therapy2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovirAnticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cellsAnalysis of human cytomegalovirus oriLyt sequence requirements in the context of the viral genome.AT excursion: a new approach to predict replication origins in viral genomes by locating AT-rich regions.Nonrandom clusters of palindromes in herpesvirus genomesThe human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10)Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.Host-viral effects of chromatin assembly factor 1 interaction with HCMV IE2The variable 3' ends of a human cytomegalovirus oriLyt transcript (SRT) overlap an essential, conserved replicator element.Evidence that the UL84 gene product of human cytomegalovirus is essential for promoting oriLyt-dependent DNA replication and formation of replication compartments in cotransfection assaysIdentification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7.Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine.Strand compositional asymmetry in bacterial and large viral genomes.Identification of a large bent DNA domain and binding sites for serum response factor adjacent to the NFI repeat cluster and enhancer region in the major IE94 promoter from simian cytomegalovirus.cis-acting elements in the lytic origin of DNA replication of Epstein-Barr virusIdentification of a lytic-phase origin of DNA replication in human herpesvirus 6B strain Z29.Primary structure of the herpesvirus saimiri genome.Human cytomegalovirus induces JC virus DNA replication in human fibroblasts.Human cytomegalovirus origin of DNA replication (oriLyt) resides within a highly complex repetitive region.Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene controlReplication of Epstein-Barr virus oriLyt: lack of a dedicated virally encoded origin-binding protein and dependence on Zta in cotransfection assays.The human cytomegalovirus origin of DNA replication (oriLyt) is the critical cis-acting sequence regulating replication-dependent late induction of the viral 1.2-kilobase RNA promoter.The lytic origin of herpesvirus papio is highly homologous to Epstein-Barr virus ori-Lyt: evolutionary conservation of transcriptional activation and replication signals.trans-acting requirements for replication of Epstein-Barr virus ori-Lyt.Identification of persistent RNA-DNA hybrid structures within the origin of replication of human cytomegalovirus.Human cytomegalovirus oriLyt sequence requirements.Identification of a novel transcriptional repressor encoded by human cytomegalovirus.Nucleocytoplasmic shuttling of human cytomegalovirus UL84 is essential for virus growth.Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication.Expression of human cytomegalovirus UL36 and UL37 genes is required for viral DNA replication.Four of eleven loci required for transient complementation of human cytomegalovirus DNA replication cooperate to activate expression of replication genes.Defined large-scale alterations of the human cytomegalovirus genome constructed by cotransfection of overlapping cosmids.Initiation of lytic DNA replication in Epstein-Barr virus: search for a common family mechanism.Human cytomegalovirus DNA replicates after early circularization by concatemer formation, and inversion occurs within the concatemer.Open reading frames UL44, IRS1/TRS1, and UL36-38 are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA synthesis.Eleven loci encoding trans-acting factors are required for transient complementation of human cytomegalovirus oriLyt-dependent DNA replication.Multicomponent origin of cytomegalovirus lytic-phase DNA replication.Boundaries and structure of human cytomegalovirus oriLyt, a complex origin for lytic-phase DNA replication.
P2860
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P2860
Identification of the lytic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Identification of the lytic or ...... vir-induced chain termination.
@en
type
label
Identification of the lytic or ...... vir-induced chain termination.
@en
prefLabel
Identification of the lytic or ...... vir-induced chain termination.
@en
P2093
P2860
P1433
P1476
Identification of the lytic or ...... vir-induced chain termination.
@en
P2093
F M Hamzeh
G S Hayward
P S Lietman
P2860
P304
P407
P577
1990-12-01T00:00:00Z