Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents.
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Prediction and classification of aminoacyl tRNA synthetases using PROSITE domainsHuman microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approachestRNAs as antibiotic targetsStructure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphateDistinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational SelectionStructures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sicknessEvolution and Application of Inteins in Candida species: A ReviewDecoupling Environment-Dependent and Independent Genetic Robustness across Bacterial SpeciesEssentiality Assessment of Cysteinyl and Lysyl-tRNA Synthetases of Mycobacterium smegmatisNovel hybrid virtual screening protocol based on molecular docking and structure-based pharmacophore for discovery of methionyl-tRNA synthetase inhibitors as antibacterial agentsThe complex evolutionary history of aminoacyl-tRNA synthetases.Comparative proteome analysis of Bacillus anthracis with pXO1 plasmid content.From microbial gene essentiality to novel antimicrobial drug targetsBacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in MiceEscherichia coli ASKA Clone Library Harboring tRNA-Specific Adenosine Deaminase (tadA) Reveals Resistance towards Xanthorrhizol.Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesisIdentifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition.Characterization of two seryl-tRNA synthetases in albomycin-producing Streptomyces sp. strain ATCC 700974.Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites.Boron-containing inhibitors of synthetases.Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.Novel targets for antibiotics in Staphylococcus aureus.Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme.A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycinCharacterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation.Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification.Structural characterization of free-state and product-state Mycobacterium tuberculosis methionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism.
P2860
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P2860
Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@ast
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@en
type
label
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@ast
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@en
prefLabel
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@ast
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@en
P2093
P2860
P1476
Aminoacyl-tRNA synthetases: es ...... for new anti-infective agents.
@en
P2093
Ian Critchley
Nebojsa Janjic
Thale Jarvis
Urs A Ochsner
Xicheng Sun
P2860
P304
P356
10.1517/13543784.16.5.573
P407
P577
2007-05-01T00:00:00Z