Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.
about
Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta)Long-Range Regulation of V(D)J RecombinationRORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoterA nuclear matrix attachment region upstream of the T cell receptor beta gene enhancer binds Cux/CDP and SATB1 and modulates enhancer-dependent reporter gene expression but not endogenous gene expressionGenomic analysis reveals extensive gene duplication within the bovine TRB locus.A gene-targeting approach identifies a function for the first intron in expression of the alpha1(I) collagen gene.Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Ordered assembly of the V(D)J synaptic complex ensures accurate recombinationRegulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.Regulation of chromatin accessibility for V(D)J recombination.Epigenetic control of recombination in the immune systemPromoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.Gene segment selection in V(D)J recombination: accessibility and beyond.Epigenetic regulation of T cell fate and function.V(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element.The center of accessibility: Dβ control of V(D)J recombinationT cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.Lineage-specific compaction of Tcrb requires a chromatin barrier to protect the function of a long-range tethering element.Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locusKappa chain monoallelic demethylation and the establishment of allelic exclusion.Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.Regulation of T-cell receptor beta-chain gene assembly by recombination signals: the beyond 12/23 restriction.An ectopic CTCF-dependent transcriptional insulator influences the choice of Vβ gene segments for VDJ recombination at TCRβ locus.Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangementA novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3' enhancer to act as a locus control region.Turning T-cell receptor beta recombination on and off: more questions than answers.Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibilityEnhancer control of local accessibility to V(D)J recombinase.The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombinationFunctional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus.Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions.Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.
P2860
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P2860
Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Gene-targeted deletion and rep ...... J recombination accessibility.
@ast
Gene-targeted deletion and rep ...... J recombination accessibility.
@en
type
label
Gene-targeted deletion and rep ...... J recombination accessibility.
@ast
Gene-targeted deletion and rep ...... J recombination accessibility.
@en
prefLabel
Gene-targeted deletion and rep ...... J recombination accessibility.
@ast
Gene-targeted deletion and rep ...... J recombination accessibility.
@en
P2093
P2860
P356
P1476
Gene-targeted deletion and rep ...... )J recombination accessibility
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.15.7871
P407
P577
1996-07-01T00:00:00Z