Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse - sprookjes - yvandenbroek - TriplyDB

Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

http://www.wikidata.org/entity/Q36917869

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The genomic landscape of core-binding factor acute myeloid leukemias Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.Acute Myeloid Leukemia: Advancements in Diagnosis and Treatment.Proteogenomics approaches for studying cancer biology and their potential in the identification of acute myeloid leukemia biomarkers.Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia.Precision medicine in pediatric oncology: Lessons learned and next steps.Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report.Acute Myeloid Leukemia: How Do We Measure Success?Role of SHP2 in hematopoiesis and leukemogenesis.Cohesin Mutations in Myeloid Malignancies.Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia.Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia.Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing.The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group.Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma.Acute myeloid leukaemia at an early age: Reviewing the interaction between pesticide exposure and KMT2A-rearrangement.Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway.MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia.Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia.The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.ETS1 and SP1 drive DHX15 expression in acute lymphoblastic leukaemia.Distinct age-associated molecular profiles in acute myeloid leukemia defined by comprehensive clinical genomic profiling.Analysis of Racial/Ethnic Representation in Select Basic and Applied Cancer Research Studies Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors

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P2860

Genomic Profiling of Pediatric Acute Myeloid Leukemia Reveals a Changing Mutational Landscape from Disease Diagnosis to Relapse

http://www.wikidata.org/entity/Q36917869

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2016年论文

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Genomic Profiling of Pediatric ...... m Disease Diagnosis to Relapse

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Cancer Research

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Genomic Profiling of Pediatric ...... m Disease Diagnosis to Relapse

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Daniel Wai

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Heather L Schuback

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Jaime M Guidry Auvil

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Lora R Lewis

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P2860

Comprehensive molecular characterization of human colon and rectal cancer

Recurring mutations found by sequencing an acute myeloid leukemia genome

DNMT3A Mutations in Acute Myeloid Leukemia

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.

Prognostic impact of FLT3-ITD load in NPM1 mutated acute myeloid leukemia.

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

Prediction of deleterious human alleles

Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.

Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children’s Oncology Group trial AAML0531.

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Malcolm A Smith

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