Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin
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Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer TherapyThe hepatic cannabinoid 1 receptor as a modulator of hepatic energy state and food intakeOrganic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugsMembrane transporters in drug developmentInvestigation of microcystin congener-dependent uptake into primary murine neurons.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Synergistic interaction between genetics and disease on pravastatin dispositionInteraction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.The SLCO (former SLC21) superfamily of transporters.Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice.PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3.Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis.Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice.Contribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearanceOrganic anion transporting polypeptides in the hepatic uptake of PBDE congeners in miceInfluence of polymorphic OATP1B-type carriers on the disposition of docetaxel.Effect of anti-tuberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug.Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.OATP1B1 polymorphism as a determinant of erythromycin disposition.Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronideDrug-drug interaction studies: regulatory guidance and an industry perspectiveInherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia.Modulation of OATP1B-type transporter function alters cellular uptake and disposition of platinum chemotherapeutics.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Organic anion uptake by hepatocytes.Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics.Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes.Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.Hormonal regulation of hepatic drug biotransformation and transport systems.Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions.Influence of drug formulation on OATP1B-mediated transport of paclitaxel.Sorafenib metabolism, transport, and enterohepatic recycling: physiologically based modeling and simulation in mice.Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter.Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.Membrane Transporters for Bilirubin and Its Conjugates: A Systematic Review.Tissue-specific changes in mRNA expression of Abc and Slc transporters in murine pulmonary tuberculosis.
P2860
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P2860
Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Targeted disruption of murine ...... rates pravastatin and rifampin
@en
type
label
Targeted disruption of murine ...... rates pravastatin and rifampin
@en
prefLabel
Targeted disruption of murine ...... rates pravastatin and rifampin
@en
P2093
P2860
P356
P1476
Targeted disruption of murine ...... rates pravastatin and rifampin
@en
P2093
Hani Zaher
Jeffrey L Stock
Joe Palandra
Joseph A Ware
Leslie A Obert
Melissa L Cox
Nidhi Agrawal
Richard B Kim
Rommel G Tirona
P2860
P304
P356
10.1124/MOL.108.046458
P577
2008-04-15T00:00:00Z