RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. - sprookjes - yvandenbroek - TriplyDB

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

http://www.wikidata.org/entity/Q36931209

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Converging roles of caspases in inflammasome activation, cell death and innate immunity Photoreceptor cell death and rescue in retinal detachment and degenerations The two faces of receptor interacting protein kinase-1 Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis Emerging Roles for the Immune System in Traumatic Brain Injury Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity.Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3 SHP-1 and IL-1α conspire to provoke neutrophilic dermatoses.Advances in kinase inhibition: treating rheumatic diseases and beyond.Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis.NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis.OligoG CF-5/20 Disruption of Mucoid Pseudomonas aeruginosa Biofilm in a Murine Lung Infection Model.Autoinflammatory Skin Disorders: The Inflammasomme in Focus.RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.Distinct role of IL-1β in instigating disease in Sharpincpdm mice.Interleukin 1α and the inflammatory process.Critical role for inflammasome-independent IL-1β production in osteomyelitis.Necrosis-dependent and independent signaling of the RIP kinases in inflammation.Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.Novel roles for caspase-8 in IL-1β and inflammasome regulation.Interleukin-1α and brain inflammation.Necroinflammation in Kidney Disease.Emerging Roles for RIPK1 and RIPK3 in Pathogen-Induced Cell Death and Host Immunity.Necroptosis: a potential, promising target and switch in acute pancreatitis.Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma.Protein tyrosine phosphatase SHP-1: resurgence as new drug target for human autoimmune disorders.Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1.

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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

http://www.wikidata.org/entity/Q36931209

description

2013 nî lūn-bûn

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2013年論文

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2013年论文

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2013年论文

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name

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

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type

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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

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RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

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Gordon R Johnson

http://www.w3.org/2001/XMLSchema#string

Michelle A Kelliher

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Mohamed Lamkanfi

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P2860

Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

Sterile inflammation: sensing and reacting to damage

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.

Identification of polymorphisms in the human SHP1 gene.

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10.1038/NATURE12174

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7453

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498

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Thirumala-Devi Kanneganti

Yoichiro Iwakura

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2013-05-26T00:00:00Z

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236940080

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1035611218

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23708968

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3683390

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