Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro.
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Recombinant human parainfluenza virus type 2 with mutations in V that permit cellular interferon signaling are not attenuated in non-human primates.Progress in the development of human parainfluenza virus vaccinesGenome sequencing and phylogenetic analysis of 39 human parainfluenza virus type 1 strains isolated from 1997-2010.Identification of human parainfluenza virus type 2 (HPIV-2) V protein amino acid residues that reduce binding of V to MDA5 and attenuate HPIV-2 replication in nonhuman primatesNonsegmented negative-strand viruses as vaccine vectors.Progress in understanding and controlling respiratory syncytial virus: still crazy after all these yearsAttenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes.Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine.Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates.The cDNA-derived investigational human parainfluenza virus type 3 vaccine rcp45 is well tolerated, infectious, and immunogenic in infants and young childrenNew generation live vaccines against human respiratory syncytial virus designed by reverse genetics.Increased genetic and phenotypic stability of a promising live-attenuated respiratory syncytial virus vaccine candidate by reverse geneticsLive vaccines for human metapneumovirus designed by reverse genetics.Role of interferon in the replication of human parainfluenza virus type 1 wild type and mutant viruses in human ciliated airway epithelium.Codon stabilization analysis of the "248" temperature sensitive mutation for increased phenotypic stability of respiratory syncytial virus vaccine candidates.A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates.RNA-based viral vectors.Progress in respiratory virus vaccine development
P2860
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P2860
Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Codon substitution mutations a ...... phenotypic stability in vitro.
@en
type
label
Codon substitution mutations a ...... phenotypic stability in vitro.
@en
prefLabel
Codon substitution mutations a ...... phenotypic stability in vitro.
@en
P2093
P2860
P1433
P1476
Codon substitution mutations a ...... phenotypic stability in vitro.
@en
P2093
Brian R Murphy
Jason T Newman
Jeffrey M Riggs
Josephine M McAuliffe
Mario H Skiadopoulos
Peter L Collins
Sonja R Surman
P2860
P304
P356
10.1128/JVI.78.4.2029-2036.2004
P407
P577
2004-02-01T00:00:00Z