The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway - sprookjes - yvandenbroek - TriplyDB

The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway

The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway

http://www.wikidata.org/entity/Q36964339

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poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis.Beyond NF-κB activation: nuclear functions of IκB kinase α Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis An IKKα-nucleophosmin axis utilizes inflammatory signaling to promote genome integrity.Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression.Induction of ΔNp63 by the newly identified keratinocyte-specific transforming growth factor β Signaling Pathway with Smad2 and IκB Kinase α in squamous cell carcinoma.Alternative nuclear functions for NF-κB family members IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin IκB kinase alpha and cancer IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivation.Cutaneous clear cell/signet-ring cell squamous cell carcinoma arising in the right thigh of a patient with type 2 diabetes: combined morphologic, immunohistochemical, and etiologic analysis.The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis.Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer.IKKα regulates human keratinocyte migration through surveillance of the redox environment.Role of IKKα in skin squamous cell carcinomas.A symphony of regulations centered on p63 to control development of ectoderm-derived structures.NF-κB and chromatin: ten years on the path from basic mechanisms to candidate drugs.The mechanistic basis for psoriasis immunopathogenesis: translating genotype to phenotype. Report of a workshop, Venice, 2012.Non-conventional functions for NF-κB members: the dark side of NF-κB.Novel functions of chromatin-bound IκBα in oncogenic transformation.COX2 overexpression is a prognostic marker for Stage III breast cancer.Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma.Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma.IKKα restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation.A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.Silencing of the cell cycle checkpoint gene 14-3-3σ in basal cell carcinomas correlates with reduced expression of IKK-α.PKCη promotes a proliferation to differentiation switch in keratinocytes via upregulation of p27Kip1 mRNA through suppression of JNK/c-Jun signaling under stress conditions.NF-κB Members Left Home: NF-κB-Independent Roles in Cancer.Shared molecular networks in orofacial and neural tube development

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P2860

The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway

http://www.wikidata.org/entity/Q36964339

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

The tumor suppressor activity ...... beta antiproliferative pathway

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The tumor suppressor activity ...... beta antiproliferative pathway

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The tumor suppressor activity ...... beta antiproliferative pathway

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The tumor suppressor activity ...... beta antiproliferative pathway

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P2093

Alessandro Giunta

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Barbara Marinari

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Costanza Ballaro

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Elisabetta Botti

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Francesca Moretti

http://www.w3.org/2001/XMLSchema#string

Giovanni Monteleone

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Maria Laura Giustizieri

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Marina Papoutsaki

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Michael Karin

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Pascal Descargues

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P2860

A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas

TGFbeta signaling in growth control, cancer, and heritable disorders

Transforming growth factor-beta induces development of the T(H)17 lineage

Regulation and function of IKK and IKK-related kinases

The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice

Specificity and versatility in tgf-beta signaling through Smads

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

How cells read TGF-beta signals

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.

Genetic events and the role of TGF beta in epithelial tumour progression.

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17091-17096

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10.1073/PNAS.0809288105

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44

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105

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Antonio Costanzo

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2008-10-28T00:00:00Z

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23425248

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18957551

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2579383

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