The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells
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Targeting DNA topoisomerase II in cancer chemotherapyThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageThe E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex - a potentially new drug targetInteractions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavagePhosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons.Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingUse of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.Quinolones: action and resistance updated.Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.In vitro action of flavonoids in the canine malignant histiocytic cell line DH82.Resveratrol acts as a topoisomerase II poison in human glioma cells.Genotoxicity of dietary, environmental and therapeutic topoisomerase II poisons is uniformly correlated to prolongation of enzyme DNA residence.Topoisomerase IIalpha-dependent induction of a persistent DNA damage response in response to transient etoposide exposure.High levels of topoisomerase IIalpha protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment.Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein.Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases.Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements.Measurement of Drug-Stabilized Topoisomerase II Cleavage Complexes by Flow Cytometry.Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.A flow cytometry-based method for a high-throughput analysis of drug-stabilized topoisomerase II cleavage complexes in human cells.Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβToxicology and Safety of FlavonoidsGenistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle
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The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The efficacy of topoisomerase ...... ed cleavage complexes in cells
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The efficacy of topoisomerase ...... d cleavage complexes in cells.
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type
label
The efficacy of topoisomerase ...... ed cleavage complexes in cells
@en
The efficacy of topoisomerase ...... d cleavage complexes in cells.
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prefLabel
The efficacy of topoisomerase ...... ed cleavage complexes in cells
@en
The efficacy of topoisomerase ...... d cleavage complexes in cells.
@nl
P2860
P356
P1433
P1476
The efficacy of topoisomerase ...... ed cleavage complexes in cells
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P2093
Neil Osheroff
Omari J Bandele
P2860
P304
11900-11908
P356
10.1021/BI800981J
P407
P577
2008-10-16T00:00:00Z