Effects on RNAi of the tight structure, sequence and position of the targeted region.
about
A computational study of off-target effects of RNA interferenceSmall interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral productionHIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genomeA potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposonUse of Transgenic Animals to Improve Human Health and Animal ProductionStructural rearrangements in RNA on the binding of an antisense oligonucleotide: implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents with enhanced efficacy.Gene discovery by ribozyme and siRNA libraries.Genome-wide application of RNAi to the discovery of potential drug targets.Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features.HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTRA structural analysis of in vitro catalytic activities of hammerhead ribozymes.Interfering RNA and HIV: reciprocal interferencesTranscriptome-wide prediction of miRNA targets in human and mouse using FASTH.Comparing 2-nt 3' overhangs against blunt-ended siRNAs: a systems biology based study.Modified dsRNAs that are not processed by Dicer maintain potency and are incorporated into the RISCInhibition of PAX2 gene expression by siRNA (polyethylenimine) in experimental model of obstructive nephropathy.Thermodynamics of RNA-RNA binding.Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsEvolutionary constraints to viroid evolution.Unravelling the general properties of siRNAs: strength in numbers and lessons from the past.Effect of target secondary structure on RNAi efficiency.Inhibition of hepatitis C virus replication by intracellular delivery of multiple siRNAs by nanosomes.siRNA efficiency: structure or sequence-that is the question.Opportunities for treating chronic hepatitis B and C virus infection using RNA interference.Effects of local mRNA structure on posttranscriptional gene silencing.Design of siRNA Therapeutics from the Molecular ScaleImpact of target mRNA structure on siRNA silencing efficiency: A large-scale studyTherapeutic potential of RNA interference in drug-resistant cancers.Delivery systems for in vivo use of nucleic Acid drugs.Small interfering ribonucleic acid design strategies for effective targeting and gene silencing.Cellular dynamics of antisense oligonucleotides and short interfering RNAs.An image-based, dual fluorescence reporter assay to evaluate the efficacy of shRNA for gene silencing at the single-cell level.Precise and efficient siRNA design: a key point in competent gene silencing.siRNAs target sites selection of ezrin and the influence of RNA interference on ezrin expression and biological characters of osteosarcoma cells.HIV evades RNA interference directed at TAR by an indirect compensatory mechanism.A new Houdini act: multiple routes for HIV-1 escape from RNAi-mediated inhibition.A study on the fundamental factors determining the efficacy of siRNAs with high C/G contents.A systematic analysis of the effect of target RNA structure on RNA interference.Positional effects and strand preference of RNA interference against hepatitis C virus target sequences.
P2860
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P2860
Effects on RNAi of the tight structure, sequence and position of the targeted region.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 03 February 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Effects on RNAi of the tight structure, sequence and position of the targeted region.
@en
Effects on RNAi of the tight structure, sequence and position of the targeted region.
@nl
type
label
Effects on RNAi of the tight structure, sequence and position of the targeted region.
@en
Effects on RNAi of the tight structure, sequence and position of the targeted region.
@nl
prefLabel
Effects on RNAi of the tight structure, sequence and position of the targeted region.
@en
Effects on RNAi of the tight structure, sequence and position of the targeted region.
@nl
P2860
P356
P1476
Effects on RNAi of the tight structure, sequence and position of the targeted region
@en
P2093
Kazunari Taira
P2860
P304
P356
10.1093/NAR/GKH221
P407
P577
2004-02-03T00:00:00Z