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Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision MedicineBlood brain barrier: a challenge for effectual therapy of brain tumorsRole of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitorsGenetics and pharmacogenetics of the leukotriene pathwayOrganic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugsCharacterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical functionPharmacogenomic insights into treatment and management of statin-induced myopathy.Frequencies of two functionally significant SNPs and their haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in six ethnic groups of Pakistani population.The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5.Genetic variation in drug transporters in ethnic populations.Impact of OATP transporters on pharmacokinetics.The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.The role of OATP1B1 and BCRP in pharmacokinetics and DDI of novel statins.Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins.Molecular mechanisms underlying the effects of statins in the central nervous system.Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren.Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4.Comparative bioinformatics, temporal and spatial expression analyses of Ixodes scapularis organic anion transporting polypeptidesMarked differences in frequencies of statin therapy relevant SLCO1B1 variants and haplotypes between Roma and Hungarian populations.Identification and Mechanistic Investigation of Drug-Drug Interactions Associated With Myopathy: A Translational Approach.Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy.Discordant associations between SLCO1B1 521T→C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146.Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug InteractionsThe effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range.Cost, effectiveness and environmental relevance of multidrug transporters in sea urchin embryos.Germline prognostic markers for urinary bladder cancer: obstacles and opportunities.Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats.Dynamic localization of hepatocellular transporters in health and disease.More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-Mediated Clearances.A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporineGermline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.Factors influencing lopinavir and atazanavir plasma concentration.Cyanobacterial toxins and liver disease.Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters.Efflux and uptake transporters as determinants of statin response.Pharmacogenomics and adverse drug reactions: the case of statins.Role of transporters in drug interactions.How much do antiretroviral drugs penetrate into the central nervous system?Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2007
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Role of OATP transporters in the disposition of drugs.
@en
Role of OATP transporters in the disposition of drugs.
@nl
type
label
Role of OATP transporters in the disposition of drugs.
@en
Role of OATP transporters in the disposition of drugs.
@nl
prefLabel
Role of OATP transporters in the disposition of drugs.
@en
Role of OATP transporters in the disposition of drugs.
@nl
P2860
P356
P1433
P1476
Role of OATP transporters in the disposition of drugs.
@en
P2860
P304
P356
10.2217/14622416.8.7.787
P50
P577
2007-07-01T00:00:00Z