Alk1 controls arterial endothelial cell migration in lumenized vessels
about
Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK.The pathobiology of vascular malformations: insights from human and model organism genetics.Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.Vascular heterogeneity and specialization in development and disease.Blood flow boosts BMP signaling to keep vessels in shape.PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10.Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size.Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology.ALK1 signaling in development and disease: new paradigms.Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia.Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
P2860
Q33779258-4267ECAC-F52B-42E4-8F22-4E3B2C09A389Q34544980-3AABA301-AE28-468A-86A9-8CB42F8E31A3Q38771567-1109A5E5-EB1E-467A-AEB3-13A579B01F51Q39326100-9EC930B2-4029-453D-AD2D-66974B1095BFQ41189488-555F1FA0-B78B-42A3-87F2-0C728CAFECDDQ42357211-DECB4123-7CF9-42EE-990C-53AEE4AC132AQ42364928-416E0C06-01C5-4AAD-98AC-56F74A8F69B3Q44839040-5571E540-E7EA-4F1B-A15D-E9B27E566EE3Q47197118-9C75197B-2100-46A9-A9ED-1BEB37BAC75BQ47705980-B4D3EBC1-2942-4C20-A687-9D18F59919B1Q47856805-D9B7ABD0-21EA-47FF-B3AA-F91FD7001A78Q49826259-B70AD8E2-4E4C-4BCD-9BA8-474723B52052Q52729201-56E045DB-C957-4F67-9882-4E87A065DE1C
P2860
Alk1 controls arterial endothelial cell migration in lumenized vessels
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 10 June 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Alk1 controls arterial endothelial cell migration in lumenized vessels
@en
Alk1 controls arterial endothelial cell migration in lumenized vessels.
@nl
type
label
Alk1 controls arterial endothelial cell migration in lumenized vessels
@en
Alk1 controls arterial endothelial cell migration in lumenized vessels.
@nl
prefLabel
Alk1 controls arterial endothelial cell migration in lumenized vessels
@en
Alk1 controls arterial endothelial cell migration in lumenized vessels.
@nl
P2860
P356
P1433
P1476
Alk1 controls arterial endothelial cell migration in lumenized vessels
@en
P2093
Elizabeth R Rochon
P2860
P304
P356
10.1242/DEV.135392
P407
P577
2016-06-10T00:00:00Z