EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
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An atlas of combinatorial transcriptional regulation in mouse and manUnderstanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease ProgressionChildren's Oncology Group's 2013 blueprint for research: bone tumorsIntercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcomaTarget gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressorsVorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK PathwaysThe endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growthNotch signaling in pediatric soft tissue sarcomasLysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells.Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2.3D tissue-engineered model of Ewing's sarcomaA zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesisAdvances in sarcoma genomics and new therapeutic targets.The first European interdisciplinary ewing sarcoma research summitTargeted therapy in Ewing sarcoma.HEY1 Leu94Met gene polymorphism dramatically modifies its biological functionsThe transcription factor CREBZF is a novel positive regulator of p53.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.A molecular function map of Ewing's sarcoma.Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis.Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.HEY1 functions are regulated by its phosphorylation at Ser-68.Therapeutic pipeline for soft-tissue sarcoma.Modeling sarcomagenesis using multipotent mesenchymal stem cells.Epigenetic and epigenomic mechanisms shape sarcoma and other mesenchymal tumor pathogenesis.The clinical development of p53-reactivating drugs in sarcomas - charting future therapeutic approaches and understanding the clinical molecular toxicology of Nutlins.The ets transcription factor Fli-1 in development, cancer and disease.Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma.CADASIL mutant NOTCH3(R90C) decreases the viability of HS683 oligodendrocytes via apoptosis.EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma.Chronic stress induces CD99, suppresses autophagy, and affects spontaneous adipogenesis in human bone marrow stromal cells.SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration.Targeted polytherapy in small cell sarcoma and its association with doxorubicin.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.Potential molecular targets for Ewing's sarcoma therapy.miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor.
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EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on September 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
@en
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma.
@nl
type
label
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
@en
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma.
@nl
prefLabel
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
@en
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma.
@nl
P2093
P2860
P1433
P1476
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma
@en
P2093
Dave N T Aryee
Gunhild Jug
Idriss M Bennani-Baiti
Karin Muehlbacher
Karl-Ludwig Schaefer
Oskar Smrzka
Raphaela Schwentner
P2860
P304
P356
10.1158/0008-5472.CAN-07-6145
P407
P577
2008-09-01T00:00:00Z