Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress
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Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its managementPADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease.Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3.Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase.Pathway-based analysis of rare and common variants to test for association with blood pressureThrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxationThrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP.Age-associated induction of cell membrane CD47 limits basal and temperature-induced changes in cutaneous blood flow.Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.Cardiac-specific NRAP overexpression causes right ventricular dysfunction in miceHeparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.CD47 deficiency protects mice from diet-induced obesity and improves whole body glucose tolerance and insulin sensitivity.Matricellular proteins in cardiac adaptation and disease.The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47.Thrombospondin-1: an extracellular message delivered by macrophages that promotes aortic aneurysmsTherapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation.CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.Advances and challenges in skeletal muscle angiogenesis.CD47 signaling pathways controlling cellular differentiation and responses to stress.Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity.Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapiesThrombospondins in the heart: potential functions in cardiac remodeling.Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.Therapies using anti-angiogenic peptide mimetics of thrombospondin-1.Thrombospondins, potential drug targets for cardiovascular diseases.Thrombospondins: old players, new gamesThrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease.Thrombospondin-1, free radicals, and the coronary microcirculation: the aging conundrum.Regulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancerNitric oxide: what's new to NO?Matricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease.Thrombospondins: A Role in Cardiovascular Disease.Thrombospondin-1, endothelium and systemic vascular tone.HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstrictionThrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix.Acute CD47 Blockade During Ischemic Myocardial Reperfusion Enhances Phagocytosis-Associated Cardiac RepairThe Roles of Thrombospondins in Hemorrhagic Stroke.
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Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 21 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Thrombospondin-1 and CD47 regu ...... responses to vasoactive stress
@en
Thrombospondin-1 and CD47 regu ...... esponses to vasoactive stress.
@nl
type
label
Thrombospondin-1 and CD47 regu ...... responses to vasoactive stress
@en
Thrombospondin-1 and CD47 regu ...... esponses to vasoactive stress.
@nl
prefLabel
Thrombospondin-1 and CD47 regu ...... responses to vasoactive stress
@en
Thrombospondin-1 and CD47 regu ...... esponses to vasoactive stress.
@nl
P2093
P2860
P1433
P1476
Thrombospondin-1 and CD47 regu ...... responses to vasoactive stress
@en
P2093
Daryl Despres
Jeff S Isenberg
John M Sipes
Jurgen Schnermann
Justin B Maxhimer
William A Frazier
P2860
P304
P356
10.1016/J.MATBIO.2009.01.002
P577
2009-01-21T00:00:00Z