Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.
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Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission TomographyThe Simplest Flowchart Stating the Mechanisms for Organic Xenobiotics-induced Toxicity: Can it Possibly be Accepted as a "Central Dogma" for Toxic Mechanisms?Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.The generation, detection, and effects of reactive drug metabolites.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents.Design and synthesis of the stabilized analogs of belactosin A with the unnatural cis-cyclopropane structure.Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.Metabolism-guided drug design
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Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 March 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of biotransformation stud ...... liabilities in drug discovery.
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Role of biotransformation stud ...... liabilities in drug discovery.
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type
label
Role of biotransformation stud ...... liabilities in drug discovery.
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Role of biotransformation stud ...... liabilities in drug discovery.
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prefLabel
Role of biotransformation stud ...... liabilities in drug discovery.
@en
Role of biotransformation stud ...... liabilities in drug discovery.
@nl
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P2860
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Role of biotransformation stud ...... liabilities in drug discovery.
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Benjamin M Johnson
Tian J Yang
Yue-Zhong Shu
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P2888
P304
P356
10.1208/S12248-008-9016-9
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P577
2008-03-13T00:00:00Z
P5875
P6179
1041313702