Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury
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The complex and central role of interferon-γ in graft-versus-host disease and graft-versus-tumor activityIFN-γ mediates graft-versus-breast cancer effects via enhancing cytotoxic T lymphocyte activity.Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses.Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras.Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host diseaseIFN-γ promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation.Indoleamine 2,3-dioxygenase in human hematopoietic stem cell transplantation.Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in miceIFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cellsIFN-γ and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity.Activated CD8 T cells acquire NK1.1 expression and preferentially locate in the liver in mice after allogeneic hematopoietic cell transplantationAllogeneic Th1 cells home to host bone marrow and spleen and mediate IFNγ-dependent aplasia.Programming of donor T cells using allogeneic δ-like ligand 4-positive dendritic cells to reduce GVHD in mice.Dichotomous role of interferon-gamma in allogeneic bone marrow transplant.Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.Targeting Cytokines in GVHD Therapy.Pre-transplant arm muscle area: a simple measure to identify patients at risk.Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells.Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-γ.PD-L1 serves as a double agent in separating GVL from GVHD.Dendritic polyglycerol sulfate attenuates murine graft-versus-host disease.The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay.
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P2860
Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Paradoxical effects of IFN-gam ...... on of epithelial tissue injury
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Paradoxical effects of IFN-gam ...... n of epithelial tissue injury.
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type
label
Paradoxical effects of IFN-gam ...... on of epithelial tissue injury
@en
Paradoxical effects of IFN-gam ...... n of epithelial tissue injury.
@nl
prefLabel
Paradoxical effects of IFN-gam ...... on of epithelial tissue injury
@en
Paradoxical effects of IFN-gam ...... n of epithelial tissue injury.
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P2093
P2860
P1433
P1476
Paradoxical effects of IFN-gam ...... on of epithelial tissue injury
@en
P2093
Beow Yong Yeap
Megan Sykes
Min-Guang Wang
Shumei Wang
Wannee Asavaroengchai
P2860
P304
P356
10.1182/BLOOD-2008-07-168419
P407
P577
2009-02-10T00:00:00Z