Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients
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Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients.Recent clinical trials of cancer immunogene therapy in companion animals.Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironmentA case report of a patient with metastatic ocular melanoma who experienced a response to treatment with the BRAF inhibitor vemurafenib.Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists.Tumor-directed immunotherapy can generate tumor-specific T cell responses through localized co-stimulationLocal irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients.DNA damage induced by human CD40 ligand mutant promotes senescence and induces demethylation of GATA4 in lung cancer.CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy
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Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 March 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Immunostimulatory AdCD40L gene ...... n metastatic melanoma patients
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Immunostimulatory AdCD40L gene ...... metastatic melanoma patients.
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type
label
Immunostimulatory AdCD40L gene ...... n metastatic melanoma patients
@en
Immunostimulatory AdCD40L gene ...... metastatic melanoma patients.
@nl
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Immunostimulatory AdCD40L gene ...... n metastatic melanoma patients
@en
Immunostimulatory AdCD40L gene ...... metastatic melanoma patients.
@nl
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Immunostimulatory AdCD40L gene ...... n metastatic melanoma patients
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Aglaia Maleka
Anders Nilsson
Anders Sundin
Angelica Loskog
Christina Lundberg
Emma Svensson
Gustav Ullenhag
Johan Krause
Margrét Agnarsdóttir
Sara Mangsbo
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P2888
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10.1038/BJC.2016.42
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2016-03-31T00:00:00Z
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1051358204