Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.
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Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metaboliteDisabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant MesotheliomaSulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseasesCysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents.Reversible and irreversible protein glutathionylation: biological and clinical aspects.Detection of busulfan adducts on proteins.A comparison of reversible versus irreversible protein glutathionylation.Role of pharmacogenetics in busulfan/cyclophosphamide conditioning therapy prior to hematopoietic stem cell transplantation.Pharmacometabonomic Prediction of Busulfan Clearance in Hematopoetic Cell Transplant Recipients.The busulfan metabolite EdAG irreversibly glutathionylates glutaredoxins.Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys, and Gly.Toxicity of Glutathione-Binding Metals: A Review of Targets and Mechanisms.Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review.
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P2860
Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 12 September 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
@en
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
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type
label
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
@en
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
@nl
prefLabel
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
@en
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
@nl
P2093
P2860
P356
P1476
Dehydroalanine analog of gluta ...... lutathione S-transferase A1-1.
@en
P2093
Arthur J L Cooper
Cody J Peer
Gregory W Konat
Islam R Younis
John T Pinto
Meenal Elliott
Michal Kraszpulski
Patrick S Callery
William P Petros
P2860
P304
P356
10.1124/JPET.108.142208
P407
P577
2008-09-12T00:00:00Z