PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches
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Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignanciesEmerging targeted therapies for melanoma treatment (review)Autophagy and cancerTargeted therapy for hepatocellular carcinoma: novel agents on the horizonDiscovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathwaysPhase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors.Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.Genetic variability of the mTOR pathway and prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma.The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients.Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.Role of E542 and E545 missense mutations of PIK3CA in breast cancer: a comparative computational approach.mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors.Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells.Drugging the PI3 kinome: from chemical tools to drugs in the clinic.Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapyCooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.PIK3CA Somatic Mutation Status in Relation to Patient and Tumor Factors in Racial/Ethnic Minorities with Colorectal Cancerp110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapyPIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients.Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancerThe combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence.Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance.Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.The favorable impact of PIK3CA mutations on survival: an analysis of 2587 patients with breast cancer.Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs.The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy.Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapyDescriptive profile of PIK3CA-mutated colorectal cancer in postmenopausal women.Antitumor activity of 7RH, a discoidin domain receptor 1 inhibitor, alone or in combination with dasatinib exhibits antitumor effects in nasopharyngeal carcinoma cells.Molecular mechanisms linking endometriosis under oxidative stress with ovarian tumorigenesis and therapeutic modalities.
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P2860
PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 23 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
PIK3CA mutations in human soli ...... various therapeutic approaches
@en
PIK3CA mutations in human soli ...... arious therapeutic approaches.
@nl
type
label
PIK3CA mutations in human soli ...... various therapeutic approaches
@en
PIK3CA mutations in human soli ...... arious therapeutic approaches.
@nl
prefLabel
PIK3CA mutations in human soli ...... various therapeutic approaches
@en
PIK3CA mutations in human soli ...... arious therapeutic approaches.
@nl
P2093
P2860
P356
P1433
P1476
PIK3CA mutations in human soli ...... various therapeutic approaches
@en
P2093
Andrea Cavallaro
Ferdinando Nicoletti
Franca Stivala
Francesco Basile
Giovanni Ligresti
James A McCubrey
Linda S Steelman
Massimo Libra
P2860
P304
P356
10.4161/CC.8.9.8255
P577
2009-05-23T00:00:00Z