CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression.
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Mechanisms of TGFβ-Induced Epithelial-Mesenchymal TransitionTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsDifferential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesisCyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cellsAstrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.Role of epithelial-mesenchymal transition in gastric cancer initiation and progressionEndostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF.Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growthCdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study.PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motilityCyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomyCyclin-Dependent Kinase Inhibitors as Anticancer TherapeuticsAn immunohistochemical study of cyclin-dependent kinase 5 (CDK5) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a possible prognostic biomarker.Inhibition of endothelial Cdk5 reduces tumor growth by promoting non-productive angiogenesis.Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, ChinaActivation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cellsMicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines.MicroRNA-495 Inhibits Gastric Cancer Cell Migration and Invasion Possibly via Targeting High Mobility Group AT-Hook 2 (HMGA2).miR-137 suppresses the invasion and procedure of EMT of human breast cancer cell line MCF-7 through targeting CtBP1.The Emerging Role of Cdk5 in CancerCdk5 links with DNA damage response and cancer.Insights into the Link Between Obesity and Cancer.Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progressionCross-cancer profiling of molecular alterations within the human autophagy interaction network.Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American womenLncRNA ANCR down-regulation promotes TGF-β-induced EMT and metastasis in breast cancer.Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore.Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion.Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.Inhibition of Cdk5 induces cell death of tumor-initiating cells.Potential mechanisms underlying CDK5 related Osteosarcoma progression.The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target.Targeting Mitochondrial Ion Channels to Fight Cancer
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CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@en
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@nl
type
label
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@en
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@nl
prefLabel
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@en
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@nl
P2093
P2860
P356
P1433
P1476
CDK5 is essential for TGF-β1-i ...... and breast cancer progression.
@en
P2093
Baiqu Huang
Dong-Xu Liu
Jianchao Zhang
Jingxin Feng
Liping Wang
Pingfu Hou
Qian Liang
P2860
P2888
P356
10.1038/SREP02932
P407
P577
2013-10-14T00:00:00Z