Recovery from slow inactivation in K+ channels is controlled by water molecules.
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Elucidation of Ligand-Dependent Modulation of Disorder-Order Transitions in the Oncoprotein MDM2Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding SiteP-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscapeAn Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in (1) H-Detected Solid-State NMR Spectroscopy.Quantitative analysis of the water occupancy around the selectivity filter of a K+ channel in different gating modes.Synchrotron X-ray footprinting as a method to visualize water in proteins.Caution is required in interpretation of mutations in the voltage sensing domain of voltage gated channels as evidence for gating mechanismsSodium channel slow inactivation as a therapeutic target for myotonia congenitaVisualizing KcsA conformational changes upon ion binding by infrared spectroscopy and atomistic modeling.A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels.Simulating Current-Voltage Relationships for a Narrow Ion Channel Using the Weighted Ensemble Method.Modeling molecular kinetics with tICA and the kernel trickMechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational AnestheticsRole of protein dynamics in ion selectivity and allosteric coupling in the NaK channel.CHARMM-GUI PDB manipulator for advanced modeling and simulations of proteins containing nonstandard residues.Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Multi-ion free energy landscapes underscore the microscopic mechanism of ion selectivity in the KcsA channelHydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels.Conduits of life's spark: a perspective on ion channel research since the birth of neuron.On the role of water density fluctuations in the inhibition of a proton channelDynamics transitions at the outer vestibule of the KcsA potassium channel during gating.Lipid bilayer modules as determinants of K+ channel gating.A theoretical view of protein dynamics.Modeling ion channels: past, present, and futureComputational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function.Transmembrane allosteric energetics characterization for strong coupling between proton and potassium ion binding in the KcsA channel.Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.Hysteresis in voltage-gated channelsA relationship between three-dimensional surface hydration structures and force distribution measured by atomic force microscopy.Exploring the Dynamics of the TWIK-1 Channel.Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared SpectroscopyK+ congeners that do not compromise Na+ activation of the Na+,K+-ATPase: hydration of the ion binding cavity likely controls ion selectivity.Perspective: Markov models for long-timescale biomolecular dynamics.Size, separation, structural order, and mass density of molecules packing in water and ice.Atomic mutagenesis in ion channels with engineered stoichiometryMechanism of activation at the selectivity filter of the KcsA K+ channel.Potassium channels in the heart: structure, function and regulation.Dynamic water patterns change the stability of the collapsed filter conformation of the KcsA K+ channel.The gating cycle of a K+ channel at atomic resolution.Incorporating Born solvation energy into the three-dimensional Poisson-Nernst-Planck model to study ion selectivity in KcsA K^{+} channels.
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Recovery from slow inactivation in K+ channels is controlled by water molecules.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 28 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@en
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@nl
type
label
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@en
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@nl
prefLabel
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@en
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@nl
P2093
P2860
P356
P1433
P1476
Recovery from slow inactivation in K+ channels is controlled by water molecules.
@en
P2093
Benoît Roux
Eduardo Perozo
Jared Ostmeyer
Sudha Chakrapani
P2860
P2888
P304
P356
10.1038/NATURE12395
P407
P50
P577
2013-07-28T00:00:00Z
P5875
P6179
1045371290