Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
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Oxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2Zidovudine induces downregulation of mitochondrial deoxynucleoside kinases: implications for mitochondrial toxicity of antiviral nucleoside analogs.Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytesHIV-1, reactive oxygen species, and vascular complicationsAntiretroviral neurotoxicityRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment.Drug-induced oxidative stress and toxicity.Inherited mitochondrial genomic instability and chemical exposures.Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics.Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells.Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.Mitochondrial and Oxidative Stress Response in HepG2 Cells Following Acute and Prolonged Exposure to Antiretroviral Drugs.Structure and conformational analysis of the anti-HIV reverse transcriptase inhibitor AZT using MP2 and DFT methods. Differences with the natural nucleoside thymidine. Simulation of the 1st phosphorylation step with ATP.Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity.
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P2860
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 09 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
@en
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
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type
label
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
@en
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
@nl
prefLabel
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
@en
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
@nl
P2093
P2860
P1476
Long-term exposure to AZT, but ...... and mitochondrial dysfunction.
@en
P2093
Bill Liang
Brenda I Hernandez-Santiago
Dean J Kleinhenz
Dean P Jones
Erik R Kline
Erik R Walp
Leda Bassit
Mervi A Detorio
Roy L Sutliff
Sergey Dikalov
P2860
P2888
P356
10.1007/S12012-008-9029-8
P577
2008-12-09T00:00:00Z