Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.
about
Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Trans-chromosomal recombination within the Ig heavy chain switch region in B lymphocytes.Translocation of an antibody transgene requires AID and occurs by interchromosomal switching to all switch regions except the mu switch region.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation.Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationAltering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion.The promotion of V region hypermutation.
P2860
Q30435791-6B1F1521-1B81-4645-9B3E-7602B1ADC578Q32015309-99C1279A-85BB-44B4-8FC9-8A6924116B94Q35124628-CAA9AFE2-20B8-4A72-B6E5-8CAFDC4E6F89Q35402437-A3A94304-1AA1-44ED-9687-3933180C05E7Q36083792-813CDBDA-331E-4F09-B747-714E200C516CQ36361415-8F6D3812-93B1-4391-96BC-0E8EB2540010Q36364275-DDD3CC3F-729C-46EA-9914-D6CE7E533960Q36376764-040A3062-CA49-4BAC-81C9-4EEBB8969335Q41497161-9C12F42D-F318-4D3A-96A0-EC568B253BFFQ41817392-04CB50EB-9E2A-4E82-9875-58A353008451
P2860
Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@nl
type
label
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@nl
prefLabel
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@nl
P2093
P2860
P356
P1476
Somatic recombination of heavy ...... lin heavy chain locus in mice.
@en
P2093
P2860
P304
10321-10325
P356
10.1073/PNAS.89.21.10321
P407
P577
1992-11-01T00:00:00Z