Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.
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Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicityTherapeutic and diagnostic challenges for frontotemporal dementiaDNAJB6 Myopathies: Focused Review on an Emerging and Expanding Group of MyopathiesTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Legal but lethal: functional protein aggregation at the verge of toxicityProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesOverexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers.How the nucleus copes with proteotoxic stress.Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregationTargeting protein aggregation for the treatment of degenerative diseasesMyofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1DTDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashionInhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.Changes in C57BL6 Mouse Hippocampal Transcriptome Induced by Hypergravity Mimic Acute Corticosterone-Induced StressMolecular chaperones and proteostasis regulation during redox imbalance.Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.RNA metabolism in ALS: when normal processes become pathological.Targeting TDP-43 in neurodegenerative diseases.Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates.Nuclear trafficking in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Prions, Chaperones, and Proteostasis in Yeast.Could Sirtuin Activities Modify ALS Onset and Progression?The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosisAcetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domainQuarterly intrinsic disorder digest (January-February-March, 2014).In Vivo Formation of Vacuolated Multi-phase Compartments Lacking Membranes.Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43 kDa.Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System.Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells.
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Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
@en
Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
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type
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Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
@en
Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
@nl
prefLabel
Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
@en
Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
@nl
P2093
P2860
P356
P1476
Prion-like nuclear aggregation ...... ulated by HSP40/70 chaperones.
@en
P2093
Conrad C Weihl
Heather L True
Jieya Shao
Marc I Diamond
Maria Udan-Johns
Robert H Baloh
Rocio Bengoechea
Shaughn Bell
P2860
P304
P356
10.1093/HMG/DDT408
P577
2013-08-19T00:00:00Z