Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
about
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila.Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosisIRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells.A novel pathway for inducible nitric-oxide synthase activation through inflammasomesInfection-induced bystander-apoptosis of monocytes is TNF-alpha-mediatedIrf8-regulated genomic responses drive pathological inflammation during cerebral malaria.Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila.Immune Control of Legionella Infection: An in vivo Perspective.IRF8 mutations and human dendritic-cell immunodeficiency.Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infectionSensing bacterial infections by NAIP receptors in NLRC4 inflammasome activationPost-translational regulation of inflammasomes.Immunology taught by bacteria.Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories.The inflammasomes: molecular effectors of host resistance against bacterial, viral, parasitic, and fungal infections.Innate immunity to legionella pneumophila.Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis.
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P2860
Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 31 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@en
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@nl
type
label
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@en
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@nl
prefLabel
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@en
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@nl
P2093
P2860
P356
P1476
Restriction of Legionella pneu ...... ike receptors Naip5 and Nlrc4.
@en
P2093
Anne Fortier
Karine Doiron
Maya Saleh
Philippe Gros
P2860
P304
P356
10.1128/IAI.01546-08
P407
P577
2009-08-31T00:00:00Z