Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.
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Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosisEvolving concepts in cancer therapy through targeting sphingolipid metabolismGenistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinaseCombinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expressionAlkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage responseSphingolipids in the DNA damage response.Ceramidases, roles in sphingolipid metabolism and in health and disease.Role of neutral ceramidase in colon cancer.Purification and biochemical characterization of membrane-bound neutral ceramidase from camel brain (Camelus dromedarius).Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.Sphingolipids and their metabolism in physiology and disease.AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells.
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P2860
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 02 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Downregulation of neutral cera ...... ons for cell cycle regulation.
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Downregulation of neutral cera ...... ons for cell cycle regulation.
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type
label
Downregulation of neutral cera ...... ons for cell cycle regulation.
@en
Downregulation of neutral cera ...... ons for cell cycle regulation.
@nl
prefLabel
Downregulation of neutral cera ...... ons for cell cycle regulation.
@en
Downregulation of neutral cera ...... ons for cell cycle regulation.
@nl
P2860
P1476
Downregulation of neutral cera ...... ons for cell cycle regulation.
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P2093
Youssef H Zeidan
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P304
P356
10.1016/J.BBALIP.2009.03.012
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P577
2009-04-02T00:00:00Z