Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease. - sprookjes - yvandenbroek - TriplyDB

Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

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The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration Reduced body weight gain in ubiquilin-1 transgenic mice is associated with increased expression of energy-sensing proteins Signature changes in ubiquilin expression in the R6/2 mouse model of Huntington's disease.Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations.Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice.Ubiquitin sets the timer: impacts on aging and longevity.UPS Activation in the Battle Against Aging and Aggregation-Related Diseases: An Extended Review.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.Proteostasis of Huntingtin in Health and Disease Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease.

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Ubiquilin-1 overexpression increases the lifespan and delays accumulation of Huntingtin aggregates in the R6/2 mouse model of Huntington's disease.

http://www.wikidata.org/entity/Q37521285

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 January 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

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Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

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Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

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Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

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Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

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Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

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JOURNAL.PONE.0087513

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Ubiquilin-1 overexpression inc ...... model of Huntington's disease.

@en

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Chantelle E Terrillion

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Lydia Chang

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Mervyn J Monteiro

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Todd D Gould

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P2860

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

Herp enhances ER-associated protein degradation by recruiting ubiquilins

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology

Signal integration in the endoplasmic reticulum unfolded protein response

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Huntington's disease

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e87513

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scholarly article

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10.1371/JOURNAL.PONE.0087513

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1

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9

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Darren F. Boehning

Nathaniel Safren

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2014-01-27T00:00:00Z

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259961630

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24475300

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Huntington disease

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3903676

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