Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
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Myh11(R247C/R247C) mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity.Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous CapDifferentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves.Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?Computational modelling suggests good, bad and ugly roles of glycosaminoglycans in arterial wall mechanics and mechanobiologyConstitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and functionHypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation.Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndromeRole of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions.Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.Preexisting smooth muscle cells contribute to neointimal cell repopulation at an incidence varying widely among individual lesions.Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-β/Smad pathway in vascular smooth muscle cellsPostnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceInsights into ascending aortic aneurysm pathogenesis using in vivo and ex vivo imaging systems in angiotensin II-infused miceFibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation.Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events.Experimental in vivo and ex vivo models for the study of human aortic dissection: promises and challengesSmooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries.Specific circulating microRNA signature of bicuspid aortic valve disease.A healthy tension in translational research.Genetics of hereditary large vessel diseases.Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion.Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β SignalingTGF-β Family Signaling in Connective Tissue and Skeletal Diseases.DPY-17 and MUA-3 Interact for Connective Tissue-Like Tissue Integrity in Caenorhabditis elegans: A Model for Marfan SyndromeVascular Smooth Muscle Cells.Cell biology. Dysfunctional mechanosensing in aneurysms.Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progressionThe future is now: frontiers on display at Yale-NAVBO cardiovascular inflammation and remodeling symposium 2014.AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma.NADPH oxidase 4 attenuates cerebral artery changes during the progression of Marfan syndrome.An X-linked Myh11-CreERT2 mouse line resulting from Y to X chromosome-translocation of the Cre allele.Transforming Growth Factor-β1 Inhibits Pseudoaneurysm Formation After Aortic Patch Angioplasty.Biomechanical Phenotyping of the Murine Aorta: What Is the Best Control?Further Evidence Supporting a Protective Role of Transforming Growth Factor-β (TGFβ) in Aortic Aneurysm and Dissection.
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Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 09 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@en
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@nl
type
label
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@en
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@nl
prefLabel
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@en
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@nl
P2093
P2860
P356
P1476
Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.
@en
P2093
Arnar Geirsson
George Tellides
Harry C Dietz
Jacopo Ferruzzi
Jay D Humphrey
Lingfeng Qin
Rahmat Ali
Richard W Kim
P2860
P304
P356
10.1172/JCI69942
P407
P577
2014-01-09T00:00:00Z