Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor
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Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding ComplexThe zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways.A novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulationIntegrated analysis identifies interaction patterns between small molecules and pathwaysElucidating drug resistance in human fungal pathogens.The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn.A complex game of hide and seek: the search for new antifungalsAntifungals: Mechanism of Action and Drug Resistance.From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2.The antifungal pipeline: a reality check.Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2.Rational Discovery of (+) (S) Abscisic Acid as a Potential Antifungal Agent: a Repurposing Approach.
P2860
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P2860
Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Novel antifungal drug discover ...... rved Upc2 transcription factor
@en
Novel antifungal drug discover ...... ved Upc2 transcription factor.
@nl
type
label
Novel antifungal drug discover ...... rved Upc2 transcription factor
@en
Novel antifungal drug discover ...... ved Upc2 transcription factor.
@nl
prefLabel
Novel antifungal drug discover ...... rved Upc2 transcription factor
@en
Novel antifungal drug discover ...... ved Upc2 transcription factor.
@nl
P2093
P2860
P356
P1476
Novel antifungal drug discover ...... rved Upc2 transcription factor
@en
P2093
Chia-Yu Huang
Christina Gallo-Ebert
Denise Gallagher
Geoffrey Toner
Ilana L Stroke
Jamie Francisco
Joseph T Nickels
Maria Webb
Melissa Donigan
Melissa T Manners
P2860
P304
P356
10.1128/AAC.01677-13
P407
P577
2013-10-21T00:00:00Z