Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2. - sprookjes - yvandenbroek - TriplyDB

Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2.

Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2.

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The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.Adult chronic myelomonocytic leukemia with trisomy 11: a case report.Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA group.

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Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2.

http://www.wikidata.org/entity/Q37593486

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 20 July 2016

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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Adult acute myeloid leukemia w ...... T3A, U2AF1, FLT3-ITD and IDH2.

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Adult acute myeloid leukemia w ...... T3A, U2AF1, FLT3-ITD and IDH2.

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Adult acute myeloid leukemia w ...... T3A, U2AF1, FLT3-ITD and IDH2.

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Adult acute myeloid leukemia w ...... T3A, U2AF1, FLT3-ITD and IDH2.

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Adult acute myeloid leukemia w ...... T3A, U2AF1, FLT3-ITD and IDH2.

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Adult acute myeloid leukemia w ...... T3A, U2AF1, FLT3-ITD and IDH2.

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Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation.

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes.

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome.

Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia

High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis.

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

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10.1038/LEU.2016.196

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