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BET inhibitors in the treatment of hematologic malignancies: current insights and future prospectsBrd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expressionBET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.Chemical probes targeting epigenetic proteins: Applications beyond oncology.Exploiting Epigenetic Alterations in Prostate Cancer.BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations.MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.Cancer therapies in HIV cure research.BET Bromodomain Proteins as Cancer Therapeutic Targets.Targeting Cancer Cells with BET Bromodomain Inhibitors.Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma.Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations.BET inhibitors as novel therapeutic agents in breast cancer.Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells.Bromodomain protein BRD4 inhibitor JQ1 regulates potential prognostic molecules in advanced renal cell carcinoma.Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expressionThe Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current KnowledgeInterplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 05 June 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Targeting BET bromodomain proteins in solid tumors
@en
Targeting BET bromodomain proteins in solid tumors.
@nl
type
label
Targeting BET bromodomain proteins in solid tumors
@en
Targeting BET bromodomain proteins in solid tumors.
@nl
prefLabel
Targeting BET bromodomain proteins in solid tumors
@en
Targeting BET bromodomain proteins in solid tumors.
@nl
P2093
P2860
P356
P1433
P1476
Targeting BET bromodomain proteins in solid tumors
@en
P2093
Amanda J Redig
Frank D Eckerdt
Hidayatullah G Munshi
Katharine A Collier
Vaibhav Sahai
P2860
P304
53997-54009
P356
10.18632/ONCOTARGET.9804
P407
P5008
P577
2016-06-05T00:00:00Z
2016-08-16T00:00:00Z