Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
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Potential Gene Interactions in the Cell Cycles of Gametes, Zygotes, Embryonic Stem Cells and the Development of CancerDysregulation of ubiquitin ligases in cancerArsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligaseClonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- VinorelbineFunctional interplay between MDM2, p63/p73 and mutant p53AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249The role of MDM2 and MDM4 in breast cancer development and prevention.The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling.Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct waysSplicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage.BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function.Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cellsGlutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.Colorectal cancer carcinogenesis: a review of mechanismsmicroRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis.Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function.The Involvement of Splicing Factor hnRNP A1 in UVB-induced Alternative Splicing of hdm2.The regulation of MDM2 oncogene and its impact on human cancers.Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer.Double mutant P53 (N340Q/L344R) promotes hepatocarcinogenesis through upregulation of Pim1 mediated by PKM2 and LncRNA CUDREstradiol shows anti-skin cancer activities through decreasing MDM2 expression.LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway.Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.HIV-1 Tat potently stabilises Mdm2 and enhances viral replication.Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 statusPontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53.E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy.A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis.Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death.Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo.The Role of MDM2 in Promoting Genome Stability versus Instability.Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.Histone Deacetylase Inhibitor-Induced Autophagy in Tumor Cells: Implications for p53.Differentially Expressed mRNA Targets of Differentially Expressed miRNAs Predict Changes in The TP53 Axis and Carcinogenesis Related Pathways in Human Keratinocytes Chronically Exposed to Arsenic.
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Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2013
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Spliced MDM2 isoforms promote ...... n-of-function in tumorigenesis
@en
Spliced MDM2 isoforms promote ...... -of-function in tumorigenesis.
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type
label
Spliced MDM2 isoforms promote ...... n-of-function in tumorigenesis
@en
Spliced MDM2 isoforms promote ...... -of-function in tumorigenesis.
@nl
prefLabel
Spliced MDM2 isoforms promote ...... n-of-function in tumorigenesis
@en
Spliced MDM2 isoforms promote ...... -of-function in tumorigenesis.
@nl
P2093
P2860
P356
P1476
Spliced MDM2 isoforms promote ...... n-of-function in tumorigenesis
@en
P2093
Haiyang Yu
Jiabei Wang
Lianxin Liu
Meihua Lin
Tongsen Zheng
Xiaowen Wang
Zhaohui Feng
P2860
P2888
P356
10.1038/NCOMMS3996
P407
P50
P577
2013-01-01T00:00:00Z