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Glycine receptor mechanism elucidated by electron cryo-microscopy.Mutational analysis of the human vasoactive intestinal peptide receptor subtype VPAC(2): role of basic residues in the second transmembrane helixActivation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABASelective blocking effects of tropisetron and atropine on recombinant glycine receptorsIdentification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channelMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsRobust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric ModulatorsA neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegansGamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activityATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Relationships between structural dynamics and functional kinetics in oligomeric membrane receptorsConserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity.Design and control of acetylcholine receptor conformational changePotentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptorAllosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structureAgonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains.Allosteric gating of a large conductance Ca-activated K+ channel.Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channelsState-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor.Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsA hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.Intermediate closed state for glycine receptor function revealed by cysteine cross-linking.Ethanol modulates BKCa channels by acting as an adjuvant of calciumA unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterMonod-Wyman-Changeux allosteric mechanisms of action and the pharmacology of etomidate.Conformational selection or induced fit? 50 years of debate resolved.Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics.An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors.When is hot not so hot? Fever reduces brain inhibition.The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states.Biased AllosteryAllosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors.Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structureMutations in the extracellular amino-terminal domain of the NK2 neurokinin receptor abolish cAMP signaling but preserve intracellular calcium responses.Anesthetic and ethanol effects on spontaneously opening glycine receptor channels.Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin.Allosteric modulation as a unifying mechanism for receptor function and regulation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The multiple phenotypes of allosteric receptor mutants.
@en
The multiple phenotypes of allosteric receptor mutants.
@nl
type
label
The multiple phenotypes of allosteric receptor mutants.
@en
The multiple phenotypes of allosteric receptor mutants.
@nl
prefLabel
The multiple phenotypes of allosteric receptor mutants.
@en
The multiple phenotypes of allosteric receptor mutants.
@nl
P2093
P2860
P356
P1476
The multiple phenotypes of allosteric receptor mutants.
@en
P2093
Changeux J
Edelstein SJ
P2860
P304
P356
10.1073/PNAS.93.5.1853
P407
P577
1996-03-01T00:00:00Z