Gfi1-cells and circuits: unraveling transcriptional networks of development and disease
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From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formationErythro-megakaryocytic transcription factors associated with hereditary anemiaGfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells.Transcriptional repressors, corepressors and chromatin modifying enzymes in T cell development.Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells.The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expressionGenome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.Synergizing genomic analysis with biological knowledge to identify and validate novel genes in pancreatic development.DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring.Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.SUMOylation Regulates Growth Factor Independence 1 in Transcriptional Control and Hematopoiesis.Growth Factor Independence-1 (Gfi1) Is Required for Pancreatic Acinar Unit Formation and Centroacinar Cell DifferentiationAcute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner.SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndromeThe MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1.Gene structure and identification of minimal promoter of Pou2 expressed in spermatogonial cells of rohu carp, Labeo rohita.Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter.The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.GFI1 as a novel prognostic and therapeutic factor for AML/MDS.The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation.New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells.Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease.Enforced GFI1 expression impedes human and murine leukemic cell growth.Maternal socioeconomic disadvantage is associated with transcriptional indications of greater immune activation and slower tissue maturation in placental biopsies and newborn cord blood.GFI1 is required for RUNX1/ETO positive acute myeloid leukemia.Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.
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P2860
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on July 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease
@en
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease.
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type
label
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease
@en
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease.
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prefLabel
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease
@en
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease.
@nl
P2860
P50
P1476
Gfi1-cells and circuits: unraveling transcriptional networks of development and disease
@en
P2093
Brian Gebelein
James D Phelan
P2860
P304
P356
10.1097/MOH.0B013E32833A06F8
P577
2010-07-01T00:00:00Z