about
1-(2-Nitrophenyl)thiosemicarbazides: a novel class of potent, orally active non-peptide antagonist for the bradykinin B(2) receptorSulfonamido-aryl ethers as bradykinin B1 receptor antagonists.Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptorThe impact of aromatic ring count on compound developability--are too many aromatic rings a liability in drug design?The graphical representation of ADME-related molecule properties for medicinal chemists.The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types.Physicochemical descriptors of aromatic character and their use in drug discovery.Heterocyclic replacements for benzene: Maximising ADME benefits by considering individual ring isomers.Nonpeptide bradykinin B2 receptor antagonists: conversion of rodent-selective bradyzide analogues into potent, orally-active human bradykinin B2 receptor antagonists.Potent and orally bioavailable non-peptide antagonists at the human bradykinin B(1) receptor based on a 2-alkylamino-5-sulfamoylbenzamide core.Chemoinformatics: manipulating chemical information to facilitate decision-making in drug discovery.Should medicinal chemists do molecular modelling?Analysis of the calculated physicochemical properties of respiratory drugs: can we design for inhaled drugs yet?How drug-like are 'ugly' drugs: do drug-likeness metrics predict ADME behaviour in humans?
P50
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description
hulumtues
@sq
researcher
@en
wetenschapper
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հետազոտող
@hy
name
Timothy J Ritchie
@nl
Timothy J Ritchie
@sl
Timothy J. Ritchie
@en
Timothy J. Ritchie
@es
type
label
Timothy J Ritchie
@nl
Timothy J Ritchie
@sl
Timothy J. Ritchie
@en
Timothy J. Ritchie
@es
prefLabel
Timothy J Ritchie
@nl
Timothy J Ritchie
@sl
Timothy J. Ritchie
@en
Timothy J. Ritchie
@es
P106
P1153
7006530126
P21
P31
P496
0000-0001-7576-1267