about
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KITThe potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoidsThe role of histone demethylases in cancer therapyPhenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoniMolecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoniChemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitorsAminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship StudyStructure-Based Development of an Affinity Probe for Sirtuin 2Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of SchistosomiasisSubstituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylasesLestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cellsSelectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative ActivityPharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plantsEvolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases.Augmented reversible photoswitching of drug-target interaction through "surface borrowing".Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors.KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases.Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.Malony-CoA inhibits the S113L variant of carnitine-palmitoyltransferase II.Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N-Methyl-D-aspartate Receptors.Docking and binding free energy calculations of sirtuin inhibitors.Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivoAnalysis of the Resistance of Hepatitis C Virus NS5B Polymerase Inhibitors via Docking and Molecular Dynamics Simulation.Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.Application of docking and QM/MM-GBSA rescoring to screen for novel Myt1 kinase inhibitors.Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development.CamMedNP: building the Cameroonian 3D structural natural products database for virtual screening.In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials.Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5Carbamate prodrug concept for hydroxamate HDAC inhibitors.Computer- and structure-based lead design for epigenetic targets.Insights into the degradation of human elastin by matrilysin-1.Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).[Development of histone deacetylase inhibitors Potent active ingredients especially in cancer].
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hulumtues
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հետազոտող
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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Wolfgang Sippl
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6603446669
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0000 0000 7853 381X
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nb2009019591
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0000-0002-5985-9261
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1965-01-01T00:00:00Z
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lccn-nb2009019591