APP physiological and pathophysiological functions: insights from animal models.
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Origins of amyloid-βThe airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's diseaseDrug repositioning approaches for the discovery of new therapeutics for Alzheimer's diseaseThe multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesAmyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegenerationStructural aspects and physiological consequences of APP/APLP trans-dimerization.Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tauThe Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice.Can zebrafish be used as animal model to study Alzheimer's disease?Amyloid precursor protein (APP) regulates synaptic structure and functionAmyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.Combining RNA and protein profiling data with network interactions identifies genes associated with spermatogenesis in mouse and human.Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth.Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42)Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.APP Receptor? To Be or Not To Be.β amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease miceNovel Insights into the Physiological Function of the APP (Gene) Family and Its Proteolytic Fragments in Synaptic Plasticity.Redundancy and divergence in the amyloid precursor protein family.Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's diseaseBAG2 Is Repressed by NF-κB Signaling, and Its Overexpression Is Sufficient to Shift Aβ1-42 from Neurotrophic to Neurotoxic in Undifferentiated SH-SY5Y Neuroblastoma.Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.The role of drebrin in neurons.The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system.Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis?Influence of PKG on insulin signalling and GSK3 phosphorylation in SH-SY5Y cells.Drebrin in Alzheimer's Disease.Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling.Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.Minimotifs dysfunction is pervasive in neurodegenerative disorders
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APP physiological and pathophysiological functions: insights from animal models.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 July 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
APP physiological and pathophysiological functions: insights from animal models.
@en
APP physiological and pathophysiological functions: insights from animal models.
@nl
type
label
APP physiological and pathophysiological functions: insights from animal models.
@en
APP physiological and pathophysiological functions: insights from animal models.
@nl
prefLabel
APP physiological and pathophysiological functions: insights from animal models.
@en
APP physiological and pathophysiological functions: insights from animal models.
@nl
P2093
P2860
P356
P1433
P1476
APP physiological and pathophysiological functions: insights from animal models
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P2093
P2860
P2888
P356
10.1038/CR.2011.116
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2011-07-19T00:00:00Z