New pharmacological avenues for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors.
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Pharmacological Treatments Inhibiting Levodopa-Induced Dyskinesias in MPTP-Lesioned Monkeys: Brain Glutamate Biochemical CorrelatesRole for the nicotinic cholinergic system in movement disorders; therapeutic implications.The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeysLocation-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.Roles of Ca(2+)/calmodulin-dependent protein kinase II in subcellular expression of striatal N-methyl-D-aspartate receptors in l-3, 4-dihydroxyphenylalanine-induced dyskinetic rats.α7 nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe nigrostriatal damage.Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesiasNicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal functionα4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats.Population pharmacokinetic and pharmacodynamic analyses of safinamide in subjects with Parkinson's disease.Maladaptive Synaptic Plasticity in L-DOPA-Induced DyskinesiaIntracellular mGluR5 can mediate synaptic plasticity in the hippocampus.ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson's disease.Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson's disease mouse model.Targeting glutamate receptors to tackle the pathogenesis, clinical symptoms and levodopa-induced dyskinesia associated with Parkinson's disease.Levodopa-induced dyskinesias in Parkinson's disease: emerging treatmentsDopamine receptor agonists for Parkinson's disease.Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease.mGlu5, Dopamine D2 and Adenosine A2A Receptors in L-DOPA-induced Dyskinesias.Investigational drugs in Phase I and Phase II for Levodopa-induced dyskinesias.Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia.Proteomic analysis of striatum from MPTP-treated marmosets (Callithrix jacchus) with L-DOPA-induced dyskinesia of differing severity.A Meta-Analysis of Adenosine A2A Receptor Antagonists on Levodopa-Induced Dyskinesia In Vivo.Targeting metabotropic glutamate receptors as a new strategy against levodopa-induced dyskinesia in Parkinson's disease?L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats
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New pharmacological avenues for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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New pharmacological avenues fo ...... amate and adenosine receptors.
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New pharmacological avenues fo ...... amate and adenosine receptors.
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New pharmacological avenues fo ...... amate and adenosine receptors.
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New pharmacological avenues fo ...... amate and adenosine receptors.
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New pharmacological avenues fo ...... amate and adenosine receptors.
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New pharmacological avenues fo ...... amate and adenosine receptors.
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P2860
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New pharmacological avenues fo ...... amate and adenosine receptors.
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P2093
Fabio Blandini
Marie-Therese Armentero
P2860
P304
P356
10.1517/13543784.2012.651457
P407
P577
2012-01-11T00:00:00Z