Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex.
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Allostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary StatesRevisiting and revising the purinosomeSevering of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase.NMR crystallography of enzyme active sites: probing chemically detailed, three-dimensional structure in tryptophan synthaseCatalytic roles of βLys87 in tryptophan synthase: (15)N solid state NMR studiesA NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus.Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting waterThe tryptophan synthase α2β2 complex: a model for substrate channeling, allosteric communication, and pyridoxal phosphate catalysis.Developmental strategies and regulation of cell-free enzyme system for ethanol production: a molecular prospective.Molecular Mechanisms of Enzyme Activation by Monovalent Cations.Stochastic thermodynamics of a chemical nanomachine: The channeling enzyme tryptophan synthase.Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity.Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan SynthaseA small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.Metabolic Complementation in Bacterial Communities: Necessary Conditions and Optimality.Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan AnaloguesParadoxical performance of tryptophan synthase gene trp1 (+) in transformations of the basidiomycete Coprinopsis cinerea.Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools.Protein stability and dynamics influenced by ligands in extremophilic complexes - a molecular dynamics investigation.A Three-Ring Circus: Metabolism of the Three Proteogenic Aromatic Amino Acids and Their Role in the Health of Plants and Animals.Arabidopsis phosphoglycerate dehydrogenase1 of the phosphoserine pathway is essential for development and required for ammonium assimilation and tryptophan biosynthesis.Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational EnsembleMetal-cation regulation of enzyme dynamics is a key factor influencing the activity of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa
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P2860
Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artículo científico
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name
Allosteric regulation of subst ...... han synthase bienzyme complex.
@en
Allosteric regulation of subst ...... han synthase bienzyme complex.
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type
label
Allosteric regulation of subst ...... han synthase bienzyme complex.
@en
Allosteric regulation of subst ...... han synthase bienzyme complex.
@nl
prefLabel
Allosteric regulation of subst ...... han synthase bienzyme complex.
@en
Allosteric regulation of subst ...... han synthase bienzyme complex.
@nl
P2860
P1476
Allosteric regulation of subst ...... han synthase bienzyme complex.
@en
P2093
Michael F Dunn
P2860
P304
P356
10.1016/J.ABB.2012.01.016
P407
P577
2012-02-02T00:00:00Z