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Signalling to eIF4E in cancerMnk kinase pathway: Cellular functions and biological outcomesAdvances in targeting signal transduction pathwaysProtein expression of eIF4E and integrin αvβ6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.Selective anti-cancer agents as anti-aging drugsMechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugsChorein addiction in VPS13A overexpressing rhabdomyosarcoma cellsDistinct recruitment of human eIF4E isoforms to processing bodies and stress granulesNotch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL.Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway.Therapeutic interventions to disrupt the protein synthetic machinery in melanoma4E-BP restrains eIF4E phosphorylationEctopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberineMicroRNA-7 control of β-cell replication.Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors.Adaptations to chronic rapamycin in mice.Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursorsDiscovery of a BTK/MNK dual inhibitor for lymphoma and leukemiapeIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cellsFirst MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapyAdaptation to chronic mTOR inhibition in cancer and in aging.Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.Targeting translation: eIF4E as an emerging anticancer drug target.Inhibition of Mnk-eIF4E pathway sensitizes the efficacy to chemotherapy in anaplastic thyroid cancer.AMP-activated Protein Kinase Up-regulates Mitogen-activated Protein (MAP) Kinase-interacting Serine/Threonine Kinase 1a-dependent Phosphorylation of Eukaryotic Translation Initiation Factor 4E.Unveiling new chemical scaffolds as Mnk inhibitors.TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis.Sulfoximine substituted quinazolines for pharmaceutical compositions US 20150005278 (A1): a patent evaluation.Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines.The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding.Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells.Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview.Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Targeting Mnks for cancer therapy.
@en
Targeting Mnks for cancer therapy.
@nl
type
label
Targeting Mnks for cancer therapy.
@en
Targeting Mnks for cancer therapy.
@nl
prefLabel
Targeting Mnks for cancer therapy.
@en
Targeting Mnks for cancer therapy.
@nl
P2093
P2860
P921
P356
P1433
P1476
Targeting Mnks for cancer therapy.
@en
P2093
Christopher Proud
Frankie Lam
Jinqiang Hou
Shudong Wang
P2860
P304
P356
10.18632/ONCOTARGET.453
P407
P577
2012-02-01T00:00:00Z