A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium.
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Pharmacology of novel treatments for COPD: are fixed dose combination LABA/LAMA synergistic?Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung diseaseThe Role of Serine Proteases and Antiproteases in the Cystic Fibrosis LungIs there still hope for single therapies: how do we set up experimental systems to efficiently test combination therapies?Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat ModelFreezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary DiseasesMeasuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials.Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer.Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD.Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastaseRecent advances in α-1-antitrypsin deficiency-related lung disease.New anti-inflammatory targets for chronic obstructive pulmonary disease.Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease.The place of inhaled corticosteroids in the treatment of chronic obstructive pulmonary disease: a narrative review.Alpha-1 Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.Synthesis and Pharmacological Evaluation of Indole Derivatives as Deaza Analogues of Potent Human Neutrophil Elastase Inhibitors.The neutrophil in chronic obstructive pulmonary disease.Neutrophil elastase in bronchiectasis.Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors.Profile of the ProAxsis active neutrophil elastase immunoassay for precision medicine in chronic respiratory disease.Feasibility of Computed Tomography in a Multicenter COPD Trial: A Study of the Effect of AZD9668 on Structural Airway Changes.Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors.The Short-term Impact of Symptom-defined COPD Exacerbation Recovery on Health Status and Lung Function.Roles of Myeloid and Lymphoid Cells in the Pathogenesis of Chronic Obstructive Pulmonary Disease.Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease
P2860
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P2860
A randomised, placebo-controlled, dose-finding study of AZD9668, an oral inhibitor of neutrophil elastase, in patients with chronic obstructive pulmonary disease treated with tiotropium.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
A randomised, placebo-controll ...... sease treated with tiotropium.
@en
A randomised, placebo-controll ...... sease treated with tiotropium.
@nl
type
label
A randomised, placebo-controll ...... sease treated with tiotropium.
@en
A randomised, placebo-controll ...... sease treated with tiotropium.
@nl
prefLabel
A randomised, placebo-controll ...... sease treated with tiotropium.
@en
A randomised, placebo-controll ...... sease treated with tiotropium.
@nl
P2093
P2860
P1476
A randomised, placebo-controll ...... sease treated with tiotropium.
@en
P2093
Christopher D O'Brien
John Perrett
Kulasiri A Gunawardena
Teresita O Aquino
P2860
P304
P356
10.3109/15412555.2011.641803
P407
P577
2012-04-01T00:00:00Z