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Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressorETS-targeted therapy: can it substitute for MEK inhibitors?Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.Functional analysis of COP1 and SPA orthologs from Physcomitrella and rice during photomorphogenesis of transgenic Arabidopsis reveals distinct evolutionary conservation.Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-α-induced apoptosisThe role of epigenetics in personalized medicine: challenges and opportunities.COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer.CSN6 deregulation impairs genome integrity in a COP1-dependent pathwayRegulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth.A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation.E3 ubiquitin ligase RFWD2 controls lung branching through protein-level regulation of ETV transcription factors.IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity.Accumulation of cholesterol and increased demand for zinc in serum-deprived RPE cells.Essential Roles of E3 Ubiquitin Ligases in p53 Regulation.HuCOP1 contributes to the regulation of DNA repair in keratinocytes.Constitutive photomorphogenesis protein 1 (COP1) and COP9 signalosome, evolutionarily conserved photomorphogenic proteins as possible targets of melatonin.The Emerging Role of TRAF7 in Tumor Development.High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer.Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness.High level of COP1 expression is associated with poor prognosis in primary gastric cancer.E3 ubiquitin ligases in cancer and implications for therapies.COP1 regulates plant growth and development in response to light at the post-translational level.Downregulation of CSN6 attenuates papillary thyroid carcinoma progression by reducing Wnt/β-catenin signaling and sensitizes cancer cells to FH535 therapy.The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53.Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brainCrosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome SystemDynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Spotlight on the role of COP1 in tumorigenesis.
@en
type
label
Spotlight on the role of COP1 in tumorigenesis.
@en
prefLabel
Spotlight on the role of COP1 in tumorigenesis.
@en
P2860
P356
P1476
Spotlight on the role of COP1 in tumorigenesis.
@en
P2860
P2888
P304
P356
10.1038/NRC3271
P407
P577
2012-06-07T00:00:00Z
P6179
1033510284