Modelling neurodegeneration in prion disease - applications for drug development.

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Modelling neurodegeneration in prion disease - applications for drug development.

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Modelling neurodegeneration in prion disease - applications for drug development.

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Modelling neurodegeneration in prion disease - applications for drug development.

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Modelling neurodegeneration in prion disease - applications for drug development.

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P1476

Modelling neurodegeneration in prion disease - applications for drug development.

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David R Brown

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Kay M Uppington

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P2860

Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

Mice devoid of PrP are resistant to scrapie

Induction of cellular prion protein gene expression by copper in neurons

Copper stimulates endocytosis of the prion protein

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.

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777-788

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scholarly article

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10.1517/17460441.2.6.777

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English

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P478

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2007-06-01T00:00:00Z

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23488996

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P921

Prion protein family