In vitro methods to support transporter evaluation in drug discovery and development.
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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionThe role of transporters in toxicity and diseaseRenal drug transporters and their significance in drug-drug interactionsRecent advances in understanding hepatic drug transportP-Glycoprotein Transport of Neurotoxic PesticidesThe Effect of Albumin on MRP2 and BCRP in the Vesicular Transport AssayQuantitative targeted proteomics for membrane transporter proteins: method and application.Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters.Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challengesIn Vitro Screening of Environmental Chemicals Identifies Zearalenone as a Novel Substrate of the Placental BCRP/ABCG2 Transporter.Absence of P-glycoprotein transport in the pharmacokinetics and toxicity of the herbicide paraquat.Organic anion-transporting polypeptides.Emerging transporters of clinical importance: an update from the International Transporter Consortium.Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues.In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.Nature and uses of fluorescent dyes for drug transporter studies.Modulators of the human ABCC2: hope from natural sources?Transporter assays as useful in vitro tools in drug discovery and development.Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research.Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A.Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters.Review of Transporter-Related Postmarketing Requirement or Postmarketing Commitment Studies.Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.Drug Transporter Expression and Activity in Human Hepatoma HuH-7 Cells.Validation of a total IC50 method which enables in vitro assessment of transporter inhibition under semi-physiological conditions.Evaluation of P-Glycoprotein Inhibitory Potential Using a Rhodamine 123 Accumulation AssayMass balance, metabolite profile, and in vitro-in vivo comparison of clearance pathways of deleobuvir, a hepatitis C virus polymerase inhibitor.Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.Inhibition of the Human ABC Efflux Transporters P-gp and BCRP by the BDE-47 Hydroxylated Metabolite 6-OH-BDE-47: Considerations for Human Exposure.An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging.Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.Assessment of liver slices for research on metabolic drug-drug interactions in cattle.The role of active transport in the transcellular movement of the peripheral α2-adrenoceptor antagonist, MK-467: An in vitro pilot study.In Vitro Drug-Induced Liver Injury Prediction: Criteria Optimization of Efflux Transporter IC50 and Physicochemical Properties.Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes.Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.
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In vitro methods to support transporter evaluation in drug discovery and development.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
In vitro methods to support transporter evaluation in drug discovery and development.
@en
type
label
In vitro methods to support transporter evaluation in drug discovery and development.
@en
prefLabel
In vitro methods to support transporter evaluation in drug discovery and development.
@en
P2093
P2860
P356
P1476
In vitro methods to support transporter evaluation in drug discovery and development.
@en
P2093
International Transporter Consortium
K A Hoffmaster
K L R Brouwer
P2860
P304
P356
10.1038/CLPT.2013.81
P407
P577
2013-04-10T00:00:00Z