G-quadruplex structures in the human genome as novel therapeutic targets.
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Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexesA basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds.Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex.The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switchMutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine.Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models.Hit Identification of a Novel Dual Binder for h-telo/c-myc G-Quadruplex by a Combination of Pharmacophore Structure-Based Virtual Screening and Docking Refinement.A first-in-class and a fished out anticancer platinum compound: cis-[PtCl2(NH3)2] and cis-[PtI2(NH3)2] compared for their reactivity towards DNA model systems.Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compoundSelective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceDevelopment of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs.Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?Metal complex interactions with DNA.Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding.Detection of two isomeric binding configurations in a protein-aptamer complex with a biological nanopore.Targeting G-quadruplex structures with extrinsic fluorogenic dyes: promising fluorescence sensors.Epigenetic landscape of the TERT promoter: a potential biomarker for high risk AML/MDS.Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activityRNA G-quadruplexes and their potential regulatory roles in translation.Detection of G-type density in promoter sequence of colon cancer oncogenes and tumor suppressor genes.Highly Improved Electrospray Ionization-Mass Spectrometry Detection of G-Quadruplex-Folded Oligonucleotides and Their Complexes with Small Molecules.Strand-Biased Formation of G-Quadruplexes in DNA Duplexes Transcribed with T7 RNA Polymerase.Flexibility and structural conservation in a c-KIT G-quadruplex.Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications.Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers.G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy.Characterization of clinically used oral antiseptics as quadruplex-binding ligands.Formation of DNA:RNA hybrid G-quadruplexes of two G-quartet layers in transcription: expansion of the prevalence and diversity of G-quadruplexes in genomes.Benzothiazole hydrazones of furylbenzamides preferentially stabilize c-MYC and c-KIT1 promoter G-quadruplex DNAs.Mutant ATRX: uncovering a new therapeutic target for glioma.Construction of anti-parallel G-quadruplexes through sequential templated clickChemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplexInterdependence of pyrene interactions and tetramolecular G4-DNA assembly
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P2860
G-quadruplex structures in the human genome as novel therapeutic targets.
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article científic
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article scientifique
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articol științific
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articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
G-quadruplex structures in the human genome as novel therapeutic targets.
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type
label
G-quadruplex structures in the human genome as novel therapeutic targets.
@en
prefLabel
G-quadruplex structures in the human genome as novel therapeutic targets.
@en
P2860
P1433
P1476
G-quadruplex structures in the human genome as novel therapeutic targets
@en
P2093
Graziella Cimino-Reale
Joanna Bidzinska
P2860
P304
12368-12395
P356
10.3390/MOLECULES181012368
P407
P577
2013-10-08T00:00:00Z