Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
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Cap-Independent Translation in Hematological MalignanciesMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseTargeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma.Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo.4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice.Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma.RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR.The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.Alternative splicing of S6K1 promotes non-small cell lung cancer survival.Assessing Metabolic Changes in Response to mTOR Inhibition in a Mantle Cell Lymphoma Xenograft Model Using AcidoCEST MRI.The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cellsRapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells.C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy.Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation.Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia.Oscillatory mTOR inhibition and Treg increase in kidney transplantation.Cell-autonomous requirement for mammalian target of rapamycin (Mtor) in spermatogonial proliferation and differentiation in the mouse†.Inhibitors of mTOR pathway for cancer therapy, moving on from rapalogs to TORKinibs.
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P2860
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Time now to TORC the TORC? New ...... tion in lymphoid malignancies.
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type
label
Time now to TORC the TORC? New ...... tion in lymphoid malignancies.
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prefLabel
Time now to TORC the TORC? New ...... tion in lymphoid malignancies.
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P2093
P2860
P356
P1476
Time now to TORC the TORC? New ...... ition in lymphoid malignancies
@en
P2093
Anthony H Goldstone
Kate Cwynarski
Toby A Eyre
P2860
P304
P356
10.1111/BJH.12945
P407
P577
2014-05-19T00:00:00Z